Influence of hydrodynamic interactions on mechanical unfolding of proteins
نویسندگان
چکیده
We incorporate hydrodynamic interactions in a structure-based model of ubiquitin and demonstrate that the hydrodynamic coupling may reduce the peak force when stretching the protein at constant speed, especially at larger speeds. Hydrodynamic interactions are also shown to facilitate unfolding at constant force and inhibit stretching by fluid flows. (Some figures in this article are in colour only in the electronic version)
منابع مشابه
Hydrodynamic effects in proteins.
Experimental and numerical results pertaining to flow-induced effects in proteins are reviewed. Special emphasis is placed on shear-induced unfolding and on the role of solvent mediated hydrodynamic interactions in the conformational transitions in proteins.
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تاریخ انتشار 2007